xfactor fan wrote:Pan Zareta,
Would you make it easy for us, what haplotype Hyperion is? Since he's not "C" and "N".
Hyperion's sequence is a d-loop fragment inclusive of nps 15479-15819. It exhibits the following polymorphisms v. the CRS/HRS.
15483Adel*, 15491A>T*, 15494C, 15495C, 15496G, 15508insA*, 15534T, 15585A, 15602T, 15603C, 15649G, 15720A, 15771T
Asterisks indicate polymorphisms unique (among ~2000 E. caballus GenBank sequences defined by breed/type) to this particular sequence. They may or may not be valid markers. The other polymorphisms are sequence motif markers for sub-haplogroup L1 (Achilli et al. 2012, D1 in the nomenclature of Jansen et al. 2002).
Even if the unique markers are excluded this haplotype is an exact match for none of Hill's haplotypes. It does match, from nps 15479-15818, the published sequence (GenBank, 2008, EU580161) of Bower et al. defined as "TBG-8c". In the tree (Figure 2) Hyperion is in relatively close proximity to "Family 8c" (tho' far enough away that the unique markers were apparently not being ignored). Ormonde is just under "Family 8c". His mtDNA results were not precisely as expected either.
A couple of things to be mindful of -
These particular sequences are all in a haplogroup in which it is especially difficult to fully differentiate between/define haplotypes using HVS 1 d-loop (nps 15469-15834) alone.
The Ormonde and Hyperion samples came, obviously, from aged remains that may not have been stored in conditions ideal for DNA preservation.