Sires' genes form the equine placenta

Understanding pedigrees, inbreeding, dosage, etc.

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Pan Zareta
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Sires' genes form the equine placenta

Postby Pan Zareta » Mon Sep 23, 2013 7:27 am

From BH:

The term "do-it-all-dad" just took on a whole new meaning: Cornell University researchers have recently determined that, in equids at least, it’s the father’s genes that take the lead in developing the mare's placenta.

“We discovered more paternally (than maternally) expressed imprinted genes in the equid placenta, suggesting a greater contribution of placental development from the paternal genome,” said Xu Wang, PhD, research associate in the Department of Molecular Biology and Genetics at Cornell University, in Ithaca, N.Y. “And this runs counter to your first guess that the female ought to be the one controlling the placenta in her own body.”

But there are complex evolutionary advantages to this design, Wang explained, such as better management of genetic conflict between a male fetus and its mother. And from a breeding point of view, it could help explain the “maternal grandsire” phenomenon—the fact that high-performance foals often skip a generation, coming from the daughter of a champion sire...


Link to full article-
http://www.bloodhorse.com/horse-racing/articles/80828/study-sires-genes-form-the-equine-placenta#ixzz2fj1VvHlv

vineyridge
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Postby vineyridge » Wed Sep 25, 2013 7:39 am

This might be the result of the sire passing his X chromosome unmodified to his daughters, might it not?
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Pan Zareta
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Postby Pan Zareta » Wed Sep 25, 2013 9:09 pm

vineyridge wrote:This might be the result of the sire passing his X chromosome unmodified to his daughters, might it not?

Unlikely. None of the candidate imprinted genes are known to be on ECAX (see SI Appendix, Table S2 of the report linked in the BH article).

Seems to me that these findings could be more relevant to the 'sire of sires effect' than the 'broodmare sire effect'.

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Postby Joltman » Sun Sep 29, 2013 1:16 pm

Just yesterday I came across this article by JW about the topic a dozen years ago, and noting male influence on mice placentas.

The broodmare sire effect is for real and now the mechanisms are slowing being understood.

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Postby Jeff » Mon Oct 07, 2013 10:14 pm

Certainly proof that Stan's ideas about Buckpasser and the X have been exactly right. :D

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Pan Zareta
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Postby Pan Zareta » Tue Oct 08, 2013 7:13 am

Jeff wrote:Certainly proof that Stan's ideas about Buckpasser and the X have been exactly right.

No it isn't. None of the genes imprinted for preferential expression of the paternal copy in the placenta are on the X. Read the report.